| The potential benefit of bystander effects to cancer radiotherapy will also be discussed. 0000004422 00000 n 182 0 obj <> endobj Curr Cancer Drug Targets. Bystander cells manifest a multitude of biological consequences, such as genetic and epigenetic changes, alterations in gene expression, activation of signal transduction pathways, and delayed effects in their progeny.
J-STAGE, Japan Science and Technology Information Aggregator, Electronic. The figure depicts the major signaling pathways and protein kinases that have so far been shown to function within the SCN. Cancers (Basel).
On the other hand, intercellular signals can travel all throughout the body. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works.
0000002195 00000 n A rapidly growing body of experimental evidence indicates that ionizing radiation induces biological effects in non-irradiated bystander cells that have received signals from adjacent or distant irradiated cells. Traditionally, signals that reach the central nervous system are classified as …
Several mediating mechanisms have been proposed. 0000002343 00000 n Shang J, Welch D, Buonanno M, Ponnaiya B, Garty G, Olsen T, Amundson SA, Lin Q. Sci Rep. 2019 Dec 24;9(1):19758. doi: 10.1038/s41598-019-55831-2.
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The nature of such stimuli can vary widely, ranging from extracellular cues, such as the presence of EGF, to intracellular events, such as the DNA damage resulting from replicative telomere attrition. 0000002944 00000 n Google Classroom Facebook Twitter. This phenomenon, which has been termed the ionizing radiation-induced bystander effect, challenges the long-standing paradigm that radiation traversal through the nucleus of a cell is a prerequisite to elicit genetic damage or a biological response. Wideł M, Przybyszewski W, Rzeszowska-Wolny J. Postepy Hig Med Dosw (Online). Several mediating mechanisms have been proposed. 0000002508 00000 n Some forms of cell signaling are intracellular, while others are intercellular. 0000011414 00000 n
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Potential clinical implications]. 2009 Dec 25;625(1-3):156-64. doi: 10.1016/j.ejphar.2009.07.028. <<028D0CBD1A5C244B92CEFEDDFCF23EA9>]>> Bystander Effects of Nitric Oxide in Cellular Models of Anti-Tumor Photodynamic Therapy. |
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2011 Jun;4(2):79-95. doi: 10.2174/1874467211104020079. 0000009829 00000 n Space Radiation Biology for "Living in Space". External stimuli, such as optical and acoustic signals, stress, gradients of nutrients, and so on, are registered in sensory cells and are transmitted to other cells of the organism via intercellular signaling pathways. Intracellular cell signaling is a well understood process. They are causative agents for diseases including hypertension, diabetes, heart disease, and arthritis so offer new, and often more approachable, targets for … 0000010071 00000 n x�b```f`` g`2�03 �0�0p.
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Search for other works by this author on: Copyright © 2007 Japan Radiation Research Society, Impact on dose distribution and volume changes of a bioabsorbable polyglycolic acid spacer during chemo-proton therapy for a pediatric Ewing sarcoma, Application of 3D-print silica bolus for nasal NK/T-cell lymphoma radiation therapy, Radiation therapy enhanced therapeutic efficacy of anti-PD1 against gastric cancer, Stereotactic body radiotherapy using the forward-planned static-port tomotherapy for lung cancer: a novel planning technique with the newly-developed mode, Analyses of local control and survival after stereotactic body radiotherapy for pulmonary oligometastases from colorectal adenocarcinoma, About the Japanese Radiation Research Society, About the Japanese Society for Radiation Oncology, Receive exclusive offers and updates from Oxford Academic, Copyright © 2020 The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.
Rzeszowska-Wolny J, Przybyszewski WM, Widel M. Eur J Pharmacol.
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