Detailed description refers to the website via Author Webpage.
Although those 5-HT receptors that have been fully characterised and classified to date (and, hence, named with confidence) would seem to mediate the majority of the actions of 5-HT throughout the mammalian body, not all receptors for 5-HT are fully encompassed within our scheme of classification. This page was last modified at 13 November 2015. Check out, please ⇒ www.HelpWriting.net ⇐, Hello! If you wish to opt out, please close your SlideShare account. During touch, mechanoreceptors in the skin and other tissues respond to variations in pressure. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. In addition, some putative families, orphan receptors and non-GPCRs families are also included in the database. Comparison with SVMs method for the classification of subfamily of GPCRs. Thus, this process is repeated, © The Author 2006. The performance of identifying GPCRs from globular proteins. Acc, Accuracy. Compared with the existing methods, our method provides a superior performance. The receptor does not dictate what the brain will understand. Enter multiple addresses on separate lines or separate them with commas. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Thus, we only retrieved 165 proteins by excluding the two entries Q9W180 and P35369, where 30 are of acetylcholine, 43 of adrenoceptors, 38 of dopamine and 54 of serotonin. Boca Raton (FL): CRC Press/Taylor & Francis; 2013.
After such a screening procedure, the resulting dataset contains 1406 GPCRS and 2046 globular proteins. USA.gov. This illustrates that both amino acid composition and dipeptide composition can be used to classify GPCRs at family level with high accuracy. On the other hand, the dataset from the study of Elrod and Chou (2002) has been tested for the classification of GPCRs at type level with the covariant discriminant algorithm (Elrod and Chou, 2002) and the SVMs method (Bhasin and Raghava, 2005), which contains 167 GPCRs of amine family for four types, 31 are of acetylcholine, 44 of adrenoceptors, 38 of dopamine and 54 of serotonin. Based on evolutionary and biological characteristics, it is possible to classify ligand-receptor units into original families. It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Classification of cell receptors. 4. The program is freely available on request from the authors for scientific purposes, together with the accompanying manual and sample datasets. Adequate stimulus can be used to classify sensory receptors. Sensory receptors can be classified by location: Somatic sensory receptors near the surface of the skin can usually be divided into two groups based on morphology: A tonic receptor is a sensory receptor that adapts slowly to a stimulus, while a phasic receptor is a sensory receptor that adapts rapidly to a stimulus.