If Pentazocine and Naloxone Tablets are abruptly discontinued in a physically-dependent patient, a withdrawal syndrome may occur. Pentazocine and Naloxone Tablets should not be abruptly discontinued in a physically-dependent patient [see DOSAGE AND ADMINISTRATION]. Inform patients that accidental ingestion, especially by children, may result in respiratory depression or death [see WARNINGS]. Elimination of approximately 60% of the total dose occurs within 24 hours. Ask your healthcare professional how you should dispose of any medicine you do not use.
Selling or giving away Pentazocine and Naloxone Tablets is against the law. This may be increased to 2 tablets when needed. Dosage and Administration]. for every 1 mg morphine given. Because of the risks associated with accidental ingestion, misuse, and abuse, advise patients to store Pentazocine and Naloxone Tablets securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home [see WARNINGS, DRUG ABUSE AND DEPENDENCE].
see Dosage and Administration]. One hour later, naloxone 0.01 mg was injected i.v.
WARNINGS]. Narcotic drug products are generally considered to elevate biliary tract pressure for varying periods following their administration. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Risks of Use in Patients with Gastrointestinal Conditions.
If the decision is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic, prescribe the lowest effective dosages and minimum durations of concomitant use.
"Drug-seeking" behavior is very common in persons with substance use disorders. Advise nursing mothers to monitor infants for increased sleepiness (more than usual), breathing difficulties, or limpness.
Do not take more than 600 milligrams of pentazocine in a 24-hour period. -May increase dose to 2 tablets orally every 3 to 4 hours as needed Use caution.
Pentazocine and Naloxone are known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. In patients with circulatory shock, Pentazocine and Naloxone Tablets may cause vasodilation that can further reduce cardiac output and blood pressure. View NDC Code(s)NEW! They also stimulate prolactin, growth hormone (GH) secretion, and pancreatic secretion of insulin and glucagon. Marked mydriasis rather than miosis may be seen with hypoxia in overdose situations.