We are scientists!” one of them exclaimed, looking at me like I was the mad scientist in the room. “Let me be clear: it’s not.”, Even the title of his book—the part that says we don’t have to age—elicited an exasperated groan from the Harvard Medical School professor. Suddenly you are putting up red flags about your own science,” Olshansky, the Illinois professor, says. "It would be great to do something about that, and we believe we can with this molecule. The work has excited NASA, which is considering the challenge of keeping its astronauts healthy during a four-year mission to Mars. My lab shrunk to, like, four people.” When I asked his assistant if she remembers what it was like when the Pfizer paper came out, she sighed, looked down, and shook her head from side to side: “That was devastating.”. Sinclair and I were supposed to be at the gym at 5 p.m. to meet up with his 12-year-old son, Ben, and his about-to-be-80-year-old father. It’s great to see that they’re looking more forward rather than they used to. That’s the one we were on our way to visit when Sinclair’s Tesla tried to kill us. Just let the facts play out.” Even his friends call him out for how he talks about his science. Comet Found to Have Its Own Northern Lights, Ocean Carbon: Humans Outpace Ancient Volcanoes, Patterns in 66 Million Years of Earth's Climate, How Coronavirus Took Hold in N. America, Europe, Missing Ingredient in Dark Matter Theories, Strict Social Distancing, Lower COVID-19 Risk. Sinclair is a superstar among a group of researchers who have harnessed science and technology’s latest advances in an effort to parse out, for the very first time, the biological mechanisms of aging in hopes of slowing or even reversing the process. Co-founder, Board Member, Scientific Advisor David A Sinclair, PhD, AO is a Professor in the Department of Genetics and co-Director of the Paul F Glenn Center for the Biology of Aging at Harvard Medical School. Reproductive Longevity – taking the geroscience approach, Animal study shows new livers can grow in pig lymph nodes, Mending a broken heart by shielding stem cells, 3D printed blood vessel can monitor its own health, The X-factor required for bio-printed growth success, Cancer blood test maker Grail files for Nasdaq IPO, Nanotech ‘passport to the brain’ for therapeutics, The interferons are coming to senolytic aging therapies, Senolytics applied to the rejuvenation of organs, Targeting senescent cells to extend lifespan, Reversing damage to rewind the aging clock, Stem cells could identify new treatments for Parkinson’s, Psychobiome: trusting your gut for Longevity, Longevity marketing and the need for clarity, Insilico opens Pandomics box for AI target discovery, Inflammaging biotech acquired by Roche for €380m, AI app reveals your biological age – and how to slow…, When AI means artificial immortality: just ask Alexa, New immune aging drug brings Longevity and C19 hope, Neuralink reveals the “Fitbit for your brain”, Brain circuitry research key to tailored neurological treatments, New blood test diagnoses Alzheimer’s Disease decades before symptoms, Bridging the gap: artificial to biological neuron interfacing, At-home wellness biomarker test to deliver instant results, Blood biomarkers of frailty: a paradigm for aging research, Epigenetic reprogramming: the road to reversing time. Luckily, the trainer had an extra pair, and the Sinclair family got down to business. When I asked about it, he assured me with a self-confident nod that he is still bullish on resveratrol. Longevity.Technology: Sinclair’s work on partial cellular reprogramming gains some of its inspiration from the work done by Juan Carlos Belmonte at the Salk Institute, who showed that adult cells could be induced back to a pluripotent stage of their development.

David A. Sinclair’s Past and Present Advisory roles, Board Positions, Funding Sources, Licensed Inventions, Investments, Funding, and Invited Talks. If it helps them get more money to do research, that may be one of the reasons they do it.” Sierra, for his part, admits that as much as he dislikes when Sinclair shares what he is taking, “it is probably good for commercial purposes.”. David Sinclair: My latest work is focused on epigenetic reprogramming. And Metformin is leading that way, a lot more people are aware of Metformin as a potential Longevity drug. We think that aging is largely driven by epigenetic changes, structures in the nucleus that change over time, these technologies are extremely important to us. / Photo from Instagram. It is not surprising for children to be disturbed when they learn about mortality, but most of them move on, squirreling away the fear and dread until it comes bubbling back to the surface with the appearance of gray hairs, knee pain, and mental lacunas. Earlier in the day, Sinclair told me he was such a straight-talker that he had ruined the illusion of Santa Claus for his children—and yet here his son could be thinking his father might never die. Sinclair admits the thought did cross his mind, but blood is thicker than science, and now his brother is on the regimen, too. Even several of his graduate students are taking some of the pills. She managed to live another 20 years with one lung, which Sinclair says he would like to think had something to do with the fact that she took resveratrol.